Table 2.
List of antioxidants with proposed indication in reviewed evidence (selection).
| Diagnosis | Antioxidant | Ref. |
|---|---|---|
| Oligozoospemia | 2000 mcg of Lycopene twice a day | [30] |
| NAC 10 mg/kg/die, Vit C 3 mg/kg/die, Vit E 0.2 mg/kg/die, Vit A 0.06 IU/kg/die, thiamine 0.4 mg/kg/ die, riboxavin 0.1 mg/kg/die, piridoxin 0.2 mg/kg/die, nicotinamide 1 mg/kg/die, pantothenate 0.2 mg/kg/die, biotin 0.04 mg/kg/die, cyanocobalamin 0.1 mg/kg/die, ergocalciferol 8 IU/kg/die, calcium 1 mg/kg/die, magnesium 0.35 mg/kg/die, phosphate 0.45 mg/kg/die, iron 0.2 mg/kg/ die, manganese 0.01 mg/kg/die, copper 0.02 mg/kg/die, zinc 0.01 mg/kg/die |
[33] | |
| LC (2 g) | [34] | |
| CoQ10 (300 mg) | [35] | |
| 200 μg selenium orally daily, 600 mg N-acetyl-cysteine orally daily, 200 μg selenium plus 600 mg N-acetyl-cysteine orally daily | [25] | |
| CoQ10 (200 mg) | [36] | |
| Folic acid (5 mg) + zinc (66 mg) | [37] | |
| zinc sulphate 200 mg twice daily, zinc sulphate 200 mg + vitamin E 10 mg twice daily, zinc sulphate 200 mg + vitamin E 10 mg + vita- min C 5 mg twice daily |
[21] | |
| NAC (600 mg) and selenium (200 mg) | [35,38,39] | |
| Lycopene (2 mg) | [30] | |
| Selenium (200 mug) in combination with vitamin E (400 units) | [40] | |
| LC 2 g/d and LAC 1 g/d | [27,41,42] | |
| LC 3 g/d or/and LAC 3 g/d | [42] | |
| LC (2 g/d) + LAC (1 g/d) + Cinnoxicam (NSAID) 30-mg/d | [43] | |
| Asthenozoospermia | NAC (600 mg) and selenium (200 mg) | [25] |
| Lycopene (2 mg) | [30] | |
| 1 g vitamin C and 1 g vitamin E | [44] | |
| NAC (600 mg) | [29] | |
| CoQ10 (300 mg) | [35] | |
| CoQ10 (200 mg) | [36,39] | |
| l-carnitine (2 g/d) and l-acetyl-carnitine (1 g/d) | [41] | |
| LC (2 g) and LAC (1 g) | [27,41] | |
| NAC (600 mg/d orally) | [29] | |
| LC 3 g/d and LAC 3 g/d | [42] | |
| Zinc 500 mg/d | [45] | |
| LC (2 g/d) + LAC (1 g/d) + Cinnoxicam (NSAID) 30-mg/d | [43] | |
| Teratoozoospermia | l-carnitine (2 g/d) and l-acetyl-carnitine (1 g/d) | [41] |
| NAC (600 mg) and selenium (200 mg) | [39] | |
| 1 g vitamin C and 1 g vitamin E | [44] | |
| CoQ10 (200 mg) | [36] | |
| Lycopene (2 mg) | [30] | |
| vitamins C and E (400 mg each), β-carotene (18 mg), zinc (500 μmol) and selenium (1 μmol) | [46] | |
| LC 3 g/d and LAC 3 g/d | [42] | |
| LC (2 g/d) + LAC (1 g/d) + Cinnoxicam (NSAID) 30-mg/d | [43] | |
| OS | 2000 mcg of Lycopene | [30] |
| l-carnitine (2 g/d) and l-acetyl-carnitine (1 g/d) | [41] | |
| Vitamin E (400 mg) and selenium (225 g) | [47] | |
| Lycopene 6 mg Vitamin E 400 IU Vitamin C 100 mg Zinc 25 mg Selenium 26 µgm Folate 0.5 mg Garlic 1000 mg |
[48] | |
| NAC (600 mg) | [29] | |
| 1 g vitamin C and 1 g vitamin E | [44] | |
| Vitamin E (600 mg) | [49] | |
| Vitamin E (400 mg) and selenium (225 g) | [47] | |
| High SDF | Vitamin C (400 mg), vitamin E (400 mg), b-carotene (18 mg), zinc (500 mmol) and selenium (1 mmol) | [46] |
| LC (1500 mg); vitamin C (60 mg); CoQ10 (20 mg); vitamin E (10 mg); zinc (10 mg); folic acid (200 lg), selenium (50 lg); vitamin B12 (1 lg) | [22,50] | |
| Vitamin E 100 mg | [51] | |
| Improving perm function tests | Vitamin E (600 mg/d) | [49] |
| Improving success rate of ART | Vitamin C (1 g) + vitamin E (1 g) | [52] |
| Vitamin E 600, 800 or 1200 mg (no improvement in sperm parameters) | [53] | |
| Selen (300 microg/d) no improvement on standard semen parameters. | [54] | |
| Lycopene (6 mg), vitamin E (400 IU), vitamin C (100 mg), zinc (25 mg), selenium (26 g), folate (0.5 mg) and garlic (1 g) | [48] | |
| Zinc 500 mg improvement in standard sperm parameters | [45] | |
| CoQ10 300 mg orally twice daily for 12 months | [35] | |
| Live-birth rate | Vitamin E 600 mg/d improved zona binding assay | [49] |
| LC (2 g) + LAC (1 g/day) + 30-mg cinnoxicam (NSAID) | [43] | |
| Vitamin E 100 mg | [51] | |
| group 3: L-carnitine/acetyl-L-carnitine + 1 × 30-mg cinnoxicam (NSAID), L-carnitine (2 g/d) + acetyl-L-carnitine (1 g/d) | [43] | |
| Vitamin E (400 mg) and selenium (225 g) | [47] | |
| Vitamin E 100 mg | [51] | |
| Vitamin C (1 g) + vitamin E (1 g) | [52] |