Table 3.
Analysis of possible mutations in genes involved in iron uptake and transport systems.
| Genes | Function | Mutations/Alterations | |
|---|---|---|---|
| BSKP542 | BSKP713 | ||
| fhuA | Iron uptake [18] | V176F, I178V, I212L, G269D, V609G | V176F, I178V, I212L, G269D, V609G |
| fepA | Iron uptake [18] | P531A | P531A |
| fbpA | Iron uptake [18] | WT | WT |
| efeO | Iron uptake [18] | WT | WT |
| exbB | Iron uptake [18] | WT | WT |
| exbD | TonB-dependent energy transduction system reported to affect the function of Iron transporters [18] |
WT | WT |
| fiuA | Iron uptake [18] | Absent | Absent |
| fur | Iron uptake [18] | WT | WT |
| iutA | Iron uptake [18] | E160K, S285P | E160K, S285P |
| baeS | Encodes a sensor kinase protein of the two-component BaeSR signal transduction system [18,19] | L366H | L366H |
| envZ | Two-component transcriptional regulator reported to affect the expression of iron transporters [18,19] |
R289C | R289C |
| cirA | Encodes receptor which preferentially transports catecholate siderophores [18,19] | A134V, N558D | A134V, N558D |
| feoA | Ferrous iron uptake [18] | WT | WT |
| sitC * | Iron/manganese ABC transporter permease subunit [18] | Y11H, R166C | Y11H, R166C |
| apbC | Iron-sulfur cluster carrier protein [18] | P334S, I339T | P334S, I339T |
| fepG | Iron-enterobactin ABC transporter permease [18] | V63M, G206S | V63M, G206S |
| fepC | Iron-enterobactin ABC transporter ATP-binding protein [18] | T9A, I182N | T9A, I182N |
| fetB | Iron export ABC transporter permease subunit FetB [18] | WT | WT |
| fetA | Iron ABC transporter ATP-binding protein FetA [18] | S27N | S27N |
| fecA | TonB energy transducing system-dependent ferric citrate uptake receptor [20] | A9V, V16L, premature STOP codon in position aa569 | A9V, V16L, premature STOP codon in position aa569 |
| tonB | Component of inner membrane protein complex providing energy to TonB dependent transporters [19] |
G60A, A80V, insertion of 4 aa in position 103 (PKPK), P168A, E219Q | G60A, A80V, insertion of 4 aa in position 103 (PKPK), P168A, E219Q |
| fiu | Encodes receptor that preferentially transports catecholate siderophores [18,19] | D387N | D387N |
| ompR | Two-component transcriptional regulator reported to affect the expression of iron transporters [19] |
A72V | A72V |
| yicI | Transporter family [18,19] | S30N, L323Q, K358N, G624C, H653R | S30N, L323Q, K358N, G624C, H653R |
| yicJ | Transporter family [18,19] | P102L, F181Y | P102L, F181Y |
| yicL | Transporter family [18,19] | WT | WT |
| chrA * | Heavy metals transporter [19,20] | A245V, G344A | A245V, G344A |
Reference sequence, Klebsiella pneumoniae ATCC 13883; * reference sequence, Klebsiella pneumoniae CP071027.