Figure 9.
A schematic depiction of the protective potential of LT against VCR-induced neuropathy in rats. VCR increased the levels of MDA, NO, MPO, Ca2+, TNF-α, IL-1β, IL-6, and caspase-3, and reduced the GSH, SOD, CAT, and IL-10 levels in rat sciatic nerves. In this study, LT was found to significantly reduce VCR-induced oxidative stress, increase antioxidative strength, and reduce neuroinflammatory activity and apoptosis markers against VCR-induced neuropathy.