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. 2023 Mar 24;15:1119873. doi: 10.3389/fnagi.2023.1119873

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Copyright © 2023 Winsky-Sommerer, King, Iadevaia, Möller-Levet and Gerber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSEA of the transcriptome (“Total RNA”), translatome (“Translated”) and the “Buffering” and “Translation” regulatory modes defined with anota2seq. 74 significantly enriched terms (left: ID numbers) across time comparisons (bottom horizontal axis) are shown. Normalized enrichment scores (|NES|) for each term are displayed and are proportional to the circle size. The colormap refers to p-values indicated at the bottom, circles with a black border line refer to terms with FDR < 0.05. Red: terms associated with up-regulated genes (+ NES score); blue: terms associated with down-regulated genes (− NES score). 74 terms were manually allocated to 11 functional classes (colors in left vertical axis) and described in the bottom right legend.