Table 1:
Demographic and clinical characteristics of Serbian postmenopausal women with and without fracture stratified by age of menopause onset
| Variable | With Previous fracture (n = 258) | P-value | Without Previous fracture (n = 727) | P-value | All (n = 985) | ||
|---|---|---|---|---|---|---|---|
| Early menopause | Typical menopause | Early menopause | Typical menopause | ||||
| Age (yr), median (range) | 67.00 (50 – 85) | 68.00 (50 – 86) | 0.196a | 64.00 (50 – 83) | 63,00 (50 – 83) | 0.462a | 64 (50 – 86) |
| Body weight (kg), median (range) | 63.50 (41 – 100) | 65.00 (36 – 97) | 0.369a | 68.00 (40 – 100) | 69.00 (33 – 114) | 0.419a | 68.00 (33 – 114) |
| Body height (cm), median (range) | 158.00 (141 – 173) | 158.00 (134 – 173) | 0.911a | 160.00 (137 – 176) | 159.00 (135 – 177) | 0.931a | 159.00 (134 – 177) |
| BMI (kg/cm2), median (range) | 25.60 (17.50 – 37.20) | 26.50 (16,90 – 37.90) | 0.302a | 27.30 (15.40 – 42.20) | 27.30 (16.18 – 47.09) | 0.685a | 27.00 (15.40 – 47.09) |
| BMI category, n (%) | 0.041 b | 0.120b | |||||
| underweight (< 18.5) | 5 (6.4%) | 1 (0.6%) | 8 (4.2%) | 9 (1.7%) | 23 (2.3%) | ||
| normal weight (18.5–25) | 27 (34.6%) | 65 (36.1%) | 60 (31.6%) | 159 (29.6%) | 311 (31.7%) | ||
| overweight (25–30) | 34 (43.6%) | 83 (46.1%) | 71 (37.4%) | 237 (44.1%) | 425 (43.1%) | ||
| obese (>30) | 12 (15.4%) | 31 (17.2%) | 51 (26.8%) | 132 (24.6%) | 226 (22.9%) | ||
| Parent fractured hip, n (%) | 0.865b | 0.001 b | |||||
| yes | 15 (19.2%) | 33 (18,3%) | 14 (7.4%) | 90 (16.8%) | 152 (15.4%) | ||
| no | 63 (80.8%) | 147 (81.7%) | 176 (92.6%) | 447 (83.2%) | 833 (84.6%) | ||
| Current smoking, n (%) | 0.702b | 0.436b | |||||
| yes | 14 (17.9%) | 36 (20.0%) | 39 (20.5%) | 125 (23.3%) | 214 (21.7%) | ||
| no | 64 (82.1%) | 144 (80.0%) | 151 (79.5%) | 412 (76.7%) | 771 (78.3%) | ||
| Alcohol intake (3 or more units/day), n (%) | / | 0.093b | |||||
| yes | 0 (0%) | 0 (0%) | 1 (0.5%) | 0 (0%) | 1 (0.1%) | ||
| no | 78 (100.0%) | 180 (100.0%) | 189 (99.5%) | 537 (100.0%) | 984 (99.9%) | ||
| Glucocorticoids, n (%) | 0.082 b | 0.625 b | |||||
| yes | 4 (5.1%) | 22 (12.2%) | 20 (10.5%) | 50 (9.3%) | 96 (9.7%) | ||
| no | 74 (94.9%) | 158 (87.8%) | 170 (89.5%) | 487 (90.7%) | 889 (90.3%) | ||
| Rheumatoid arthritis, n (%) | 0.267b | 0.464b | |||||
| yes | 1 (1.3%) | 7 (3.9%) | 15 (7.9%) | 52 (9.7%) | 75 (7.6%) | ||
| no | 77 (98.7%) | 173 (96.1%) | 175 (92.1%) | 485 (90.3%) | 910 (92.4%) | ||
| Secondary osteoporosis, n (%) | 0.028 b | 0.441b | |||||
| yes | 6 (7.7%) | 33 (18.3%) | 34 (17.9%) | 110 (20.5%) | 183 (18.6%) | ||
| no | 72 (92.3%) | 147 (81.7%) | 156 (82.1%) | 427 (79.5%) | 802 (81.4%) | ||
| Femoral neck BMD (g/cm2), median (range) | 0.74 (0.51–0.95) | 0.77 (0.47–1.15) | 0.029 a | 0.81 (0.51–1.19) | 0.84 (0.53–1.46) | 0.002 a | 0.816 (0.47 – 1.46) |
a
Mann-Whitney U test,
b
χ2 – chi-squared test. // Note: Early menopause is defined as menopause that commences at or before the age of 45.// Typical menopause occurs after the age of 45