Table 1.
Multivariate analysis, adjusted for age, sex, and smoking habits, comparing SNPs of NR3C1 (rs6198, rs104893913, rs104893909, and rs104893911) in 384 Graves’ disease patients and 408 controls.
| SNP | Controls, N (%) | Cases, N (%) | p Value | OR | 95% CI | |
|---|---|---|---|---|---|---|
|
NR3C1 rs6198 Genotypes |
TT |
280 (68.6) |
301 (78.4) |
0.0038 | 1.627 | 1.170–2.264 |
| TC | 120 (29.4) | 80 (20.8) | ||||
| CC | 8 (2.0) | 3 (0.6) | ||||
| Alleles | T | 680 (83.3) | 682 (88.8) | 0.0017 | 1.586 | 1.187–2.128 |
| C | 136 (16.7) | 86 (11.2) | ||||
|
NR3C1 rs104893913 Genotypes |
CC |
408 (100) |
384 (100) |
N/A |
N/A |
N/A |
| CT | 0 (0) | 0 (0) | ||||
| TT | 0 (0) | 0 (0) | ||||
| Alleles | C T |
816 (100) 0 (0) |
768 (100) 0 (0) |
N/A | N/A | N/A |
|
NR3C1 rs104893909 Genotypes |
AA |
408 (100) |
384 (100) |
N/A |
N/A |
N/A |
| AT | 0 (0) | 0 (0) | ||||
| TT | 0 (0) | 0 (0) | ||||
| Alleles | A T |
816 (100) 0 (0) |
768 (100) 0 (0) |
N/A | N/A | N/A |
|
NR3C1 rs104893911 Genotypes |
AA |
408 (100) |
384 (100) |
N/A |
N/A |
N/A |
| AG | 0 (0) | 0 (0) | ||||
| GG | 0 (0) | 0 (0) | ||||
| Alleles | A G |
816 (100) 0 (0) |
768 (100) 0 (0) |
N/A | N/A | N/A |
SNP rs6198—TT = wild-type; TC = heterozygous; CC = polymorphic. SNP rs104893913—CC = wild-type; CT = heterozygous; TT = polymorphic. SNP rs104893909—AA = wild-type; AT = heterozygous; TT = polymorphic.