Table 2.
Clinical features of 384 Graves’ disease patients with different genotypes of NR3C1 rs6198.
| Characteristics | rs6198 | p Value | ||
|---|---|---|---|---|
| TT | TC | |||
| ± SD | Goiter Ultrasound (cm) | 27 ± 18 | 26 ± 18 | - |
| Age | 42 ± 13 | 45 ± 13 | - | |
| % | Sex | 0.8362 | ||
| Men | 15.9 | 13.8 | ||
| Women | 84.1 | 86.3 | ||
| Smoking habit | 0.3546 | |||
| Yes | 31.2 | 28.8 | ||
| No | 68.8 | 71.2 | ||
| TPOAb | 0.3329 | |||
| Positive | 80.9 | 75.0 | ||
| Negative | 19.1 | 25.0 | ||
| TgAb | 0.2266 | |||
| Positive | 52.3 | 46.1 | ||
| Negative | 47.7 | 53.9 | ||
| Ophthalmopathy | 0.4750 | |||
| Present | 60.3 | 90.3 | ||
| Absent | 39.7 | 9.7 | ||
TPOAb—thyroperoxidase antibody; TgAb—thyroglobulin antibody; TT—wild-type; TC—heterozygous. Note: For this analysis, the polymorphic genotype was disregarded, as there were only two observations.