Table 1.
Comparison of demography and clinicopathological features of follicular and papillary carcinomas.
| Parameter | FTC | PTC |
|---|---|---|
| Gender predilection | Females | Females |
| Age [45,67] | >50 years | <50 years |
| Risk factors | Iodine deficiency, colloid goiter. | Radiation, iodine excess and thyroiditis. |
| Genetic predisposition | <3% | <5% |
| Tumour size at presentation [60] | Large | Small |
| Multifocality [68] | Rare | Common |
| FNAC diagnosis | No | Yes |
| Tumour capsule | Yes | No |
| Capsular and vascular invasion | Common | Rare |
| Main subtypes [69,70] | 3 | >12 |
| Prevalent mutations or re-arrangements [71] | RAS, PAX8, PPARƴ, VEGFR. | BRAF, RET, VEGFR. |
| Lymph node metastasis [68,72] | Rare (<10%) | Common (20–90%) |
| Haematogenous metastasis [45,68] | Frequent (29%) | Rare (9%) |
| Standard surgical treatment | Lobectomy or total thyroidectomy | Lobectomy or total thyroidectomy with or without lymph node dissection. |
| 10-Year disease free survival [60,68] | 72% | 92% |