Table 1.

The list of proteins among the 295 identified human fallopian tube epithelial (hFTE) sEV proteins with known functions in reproductive biology.

Protein Name	Gene ID	Reproductive Function	Source
Plasma membrane calcium-transporting ATPase	PMCA4	Sperm hyperactivation and acrosome reaction	Al-Dossary, A.A. (2013) [25]
Pregnancy zone protein	PZP	Suppress T-cell function to prevent fetal rejection; Efficiently inhibits the aggregation of misfolded proteins during pregnancy	Skornicka, E. (2004) [40] Cater, H.J. (2019) [41]
Profilin 1	PFN1	Actin assembly regulator, essential for cell division and survival during embryogenesis	Witke, W. (2001) [42]
Disintegrin and metalloproteinase domain-containing protein	ADAM10	Regulate Notch signaling, early embryonic cardiovascular development	Zhang, C. (2010) [43]
Gelsolin	GSN	Actin-severing protein regulates acrosome reaction and sperm capacitation	Finkelstein, M. (2010) [44]
Tetraspanin CD9	CD9	Egg membrane protein essential for sperm-egg fusion	Miyado, K. (2000) [45]
Heat shock 70 kDa protein 2	HSPA2	Sperm fertilization ability	Feng, H.L (2001) [46]
Heat shock 90 kDa protein	HSP90	Modulate sperm capacitation via Erk1/2 and p38 MAPK signaling	Sun, P. (2021) [47]
Tubulin beta-4B chain	TUBB4B	Ciliary motility; egg, gamete transport	Yuan, S. (2021) [48]
Serpin Family G Member 1	SERPING1	Endometrial receptivity, implantation	Mirkin, S. (2005) [49]
Annexin A2	ANXA2	Critical for embryo adhesiveness to the human endometrium by RhoA activation	Garrido-Gómez, T. (2012) [50]