Table 1.
Main clinical characteristics in all patients, in patients with type 2 CRS, and in CKD patients. Statistically significant differences between subgroups are highlighted in bold.
| All Patients (N = 63) |
CRS Patients (N = 39) |
CKD Patients (N = 24) |
p-Value * | |
|---|---|---|---|---|
| Age (years) | 72 ± 10 | 66 ± 10 | 0.01 | |
| DM, N (%) | 31 (47.7) | 22 (56.4) | 9 (37.5) | 0.15 |
| eGFR (mL/min/1.73 m2) | 35 ± 15 | 37 ± 14 | 33 ± 16 | 0.18 |
| UPCR (g protein/g creatinine) | 0.39 (0.12–1.13) | 0.19 (0.10–0.52) | 1.03 (0.17–2.09) | 0.02 |
| Hemoglobin (g/dL) | 12.3(11.0–14.4) | 11.8 (11.0–14.4) | 13 (11.1–14.6) | 0.78 |
| Uric Acid (mg/dL) | 7.0 (5.9–8.4) | 6.9 (5.5–7.8) | 7.9 (6.05–8.9) | 0.17 |
| ESR (mm/h) | 33 ± 18 | 33 ± 19 | 32 ± 15 | 0.87 |
| CRP (mg/L) | 4 (2–8) | 4 (2–8) | 4 (3–8) | 0.92 |
| Glucose (mg/dL) | 107 (93–137) | 120 (98–160) | 99 (91–113) | 0.007 |
| Albumin (g/dL) | 4 (3.7–4.4) | 3.9 (3.7–4.3) | 4.2 (3.7–4.5) | 0.26 |
| Total Proteins (g/dL) | 7.0 (6.4–7.6) | 6.9 (6.3–7.5) | 7.2 (6.7–7.6) | 0.17 |
| Total cholesterol (mg/dL) | 161 ± 44 | 147 ± 40 | 184 ± 41 | 0.001 |
| Triglycerides (mg/dL) | 125 (94–178) | 104 (77–155) | 150 (118–216) | 0.006 |
| LDL cholesterol (mg/dL) | 94 ± 40 | 84 ± 35 | 110 ± 44 | 0.01 |
| HDL cholesterol (mg/dL) | 38 ± 10 | 37 ± 11 | 40 ± 10 | 0.29 |
| Ferritin (ng/mL) | 76 (43–114) | 63 (36–115) | 88 (58–112) | 0.31 |
| Calcium (mg/dL) | 9.4 (9.0–9.7) | 9.4 (9.1–9.7) | 9.4 (8.7–9.6) | 0.16 |
| Phosphorus (mg/dL) | 3.7 ± 0.7 | 3.7 ± 0.6 | 3.7 ± 0.8 | 0.83 |
| iPTH (pg/mL) | 130 (86–235) | 134 (92–176) | 128 (62–281) | 0.55 |
| hsTNI (ng/mL) | / | 25.3 (16.4–42.4) | / | / |
| BNP (pg/mL) | / | 324 (184–797) | / | / |
| Statins N (%) | 49 (79.0) | 32 (84.2) | 17 (70.8) | 0.22 |
| ACEI/ARB N (%) | 30 (48.4) | 14 (36.8) | 16 (66.7) | 0.02 |
| B-blockers N (%) | 44 (71) | 34 (89.5) | 10 (41.7) | 0.000 |
Values are expressed in mean (± SD) or median (IQR 25–75th percentiles). ACEI/ARB, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers; CKD, chronic kidney disease; CRP, C-reactive protein; CRS, cardiorenal syndrome; eGFR, estimated glomerular filtration rate; ESR, erythrocyte sedimentation rate; hs-TNI, high sensitivity troponin I; iPTH, intact parathyroid hormone; N, number; NT-proBNP, N-terminal prohormone BNP; UPCR, urinary protein to creatinine ratio. * p refers to t-test significance for normal distribution variables, Mann–Whitney test significance for nonparametric variables, or to chi-square test significance for categorical variables.