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. 2023 Apr 1;11(4):1068. doi: 10.3390/biomedicines11041068

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of Lactobacillus spp. on gut microbiota composition at the order, family, genus, and species levels in C57BL/6J mice. C57BL/6J mice (n = 6/group) were grouped into the normal control (NC) group and Amp group (Amp). The groups administered a composite formula with three strains were fed a dose of 1.6 × 10⁸ CFU/mouse (low dosage, LABL) or 4.8 × 10⁸ CFU/mouse (high dosage, LABH) from the 3rd day until the 7th day. All groups were analyzed for 16S ribosomal RNA V3-V4 gene expression in the ileum on the 12th day. (a) OTU heatmap distribution, (b) Principal coordinate analysis of Bray–Curtis dissimilarity, (c) the microbial community relative LDA score. Order level: (d) Bacillales spp.; Family levels—(e) Verrucomicrobiaceae spp., (f) Enterobacteriaceae spp., (g) Lactobacillaceae spp., (h) Erysipelotrichaceae spp.; genus level: (i) Prevotelia spp., (j) Staphylococcus spp., (k) Ruminococcus spp., (l) Bifidobacterium spp., (m) Lactobacillus spp., (n) Dorae spp., (o) Desulfovibrio spp.; species levels: (p) Lactobacillus (unidentified) spp., (q) Desulfovibrio C21_c20 spp., (r) S24-7 spp. *, compared with NC group, p < 0.05; #, compared with Amp group, p < 0.05; Ψ compared with LABL group, p < 0.05.

Effect of Lactobacillus spp. on gut microbiota composition at the order, family, genus, and species levels in C57BL/6J mice. C57BL/6J mice (n = 6/group) were grouped into the normal control (NC) group and Amp group (Amp). The groups administered a composite formula with three strains were fed a dose of 1.6 × 10⁸ CFU/mouse (low dosage, LABL) or 4.8 × 10⁸ CFU/mouse (high dosage, LABH) from the 3rd day until the 7th day. All groups were analyzed for 16S ribosomal RNA V3-V4 gene expression in the ileum on the 12th day. (a) OTU heatmap distribution, (b) Principal coordinate analysis of Bray–Curtis dissimilarity, (c) the microbial community relative LDA score. Order level: (d) Bacillales spp.; Family levels—(e) Verrucomicrobiaceae spp., (f) Enterobacteriaceae spp., (g) Lactobacillaceae spp., (h) Erysipelotrichaceae spp.; genus level: (i) Prevotelia spp., (j) Staphylococcus spp., (k) Ruminococcus spp., (l) Bifidobacterium spp., (m) Lactobacillus spp., (n) Dorae spp., (o) Desulfovibrio spp.; species levels: (p) Lactobacillus (unidentified) spp., (q) Desulfovibrio C21_c20 spp., (r) S24-7 spp. *, compared with NC group, p < 0.05; #, compared with Amp group, p < 0.05; Ψ compared with LABL group, p < 0.05.