Table 3.
Known tau PTMs induced by TBI in animal models.
| PTM | Residue | Species | Model | Timepoint | Reference |
|---|---|---|---|---|---|
| Phosphorylation | S198 | Rat | FPI | Acute | [219] |
| Chronic | [219] | ||||
| S199 | Rat | CCI | Acute | [220,221] | |
| Subacute | [220] | ||||
| S202 | Mouse | CCI | Acute | [222,223,224,225] | |
| Chronic | [210,224] | ||||
| WD | Chronic | [226,227] | |||
| Blast | Acute | [228] | |||
| Subacute | [227,229,230] | ||||
| Rat | CCI | Acute | [220] | ||
| Subacute | [220] | ||||
| Chronic | [231] | ||||
| FPI | Acute | [208,221] | |||
| Subacute | [208,221] | ||||
| Chronic | [221,232] | ||||
| T205 | Mouse | CCI | Acute | [222,223] | |
| Chronic | [210] | ||||
| WD | Chronic | [226] | |||
| Blast | Acute | [228,233] | |||
| Subacute | [229,230] | ||||
| Rat | CCI | Chronic | [231] | ||
| FPI | Acute | [208,221] | |||
| Subacute | [208,221] | ||||
| Chronic | [232] | ||||
| S212 | Mouse | Blast | Acute | [229] | |
| S214 | Mouse | WD | Chronic | [226,227] | |
| Blast | Acute | [229] | |||
| T231 | Mouse | CCI | Acute | [222,223] | |
| Chronic | [210] | ||||
| WD | Acute | [226,227] | |||
| Subacute | [226,227] | ||||
| Chronic | [226,227] | ||||
| Blast | Acute | [227] | |||
| Subacute | [8,9] | ||||
| Chronic | [227] | ||||
| Rat | WD | Acute | [234,235] | ||
| Chronic | [235] | ||||
| FPI | Acute | [208,221] | |||
| Subacute | [221] | ||||
| Chronic | [221] | ||||
| S262 | Mouse | Blast | Acute | [228] | |
| S396 | Mouse | CCI | Acute | [236] | |
| Chronic | [210] | ||||
| WD | Chronic | [227] | |||
| Blast | Acute | [228,229] | |||
| Subacute | [229] | ||||
| Rat | WD | Acute | [234,237] | ||
| Blast | Acute | [237] | |||
| S404 | Mouse | CCI | Acute | [238] | |
| Chronic | [210,238] | ||||
| WD | Chronic | [227] | |||
| Blast | Acute | [228] | |||
| S416 | Mouse | CCI | Acute | [222,223] | |
| S422 | Mouse | CCI | Acute | [236] | |
| Acetylation | K274 | Mouse | CCI | Acute | [25] |
| Subacute | [25] | ||||
| Blast | Acute | [25] | |||
| Subacute | [25] | ||||
| Chronic | [25] | ||||
| K281 | Mouse | CCI | Acute | [25] | |
| Subacute | [25] | ||||
| Blast | Acute | [25] | |||
| Subacute | [25] | ||||
| Chronic | [25] |
CCI = controlled cortical impact; WD = weight drop, FPI = fluid percussion injury, Blast = blast neurotrauma model, shock tube TBI, overpressure wave TBI, jet-flow overpressure multimodal TBI; Acute: <1 week; Subacute: 1 week–1 month; Chronic: >1 month.