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. 2023 Apr 4;11(4):1097. doi: 10.3390/biomedicines11041097

Figure 1.

Figure 1

The pathophysiological relationship between NAFLD and T2DM. AGE—advanced glycation endpoint, ChREBP—carbohydrate response element-binding protein, DAG—diacylglycerol, FFA—free fatty acids, IL-6—interleukin-6-type, IR—insulin receptor, IRS1/2—insulin receptor substrates-1 and -2, LPS—lipopolysaccharide, NAFLD—non-alcoholic fatty liver disease, PNPLA3—pathatin-like phospholipase containing 3, PKCε—protein kinase C epsilon type, RBP4—retinol 4 binding protein, SREBP1c—sterol regulatory element-binding transcription factor 1c, T2DM—type 2 diabetes mellitus, TNF-α—tumor necrosis factor.