Table 1.

Neuroprotective effect of Humanin, N/A is not applicable.

Article	Study Design	Population	Outcome Measures
Zárate, S.C. et al. (2019) [50]	In vivo study	Rat	Neuroprotective effect of humanin and relationship with ovarian hormones
Yen, K. et al. (2018) [38]	In vitro and in vivo study	SH-SY5Y cells, Mouse	Neuroprotective effect of humanin
Yen, K. et al. (2020) [40]	In vivo study	C. elegans, Mouse, Human	Circulating levels of humanin and their relation to diseases of aging and lifespan
Gong, Z. et al. (2022) [49]	Review	Mouse, Porcine	Protective effect of humanin in myocardial ischemia-reperfusion.
Kim, S.J. et al. (2021) [37]	Review	N/A	Humanin in age-related disease
Gong, Z. et al. (2014) [51]	Review	N/A	Role of humanin in age-related disease
Caso, V.M. et al. (2021) [42]	In vitro study	N/A	Neuroprotective effects of humanin and its homologs (HNG) from Aβ
Zacharias, D.G. et al. (2012) [43]	In vivo study	Mouse	Humanin reduced plaque accumulation in Alzheimer’s disease and has a cytoprotective action in stroke
Park, T. et al. (2013) [55]	In vivo study	Middle-aged APPswe/PS1dE9 mice	Treatment with HNG significantly improves spatial learning and memory deficits, reduces Aβ plaque accumulation and insoluble Aβ concentration; decreases neuro-inflammatory responses