Table 2.

Role of Humanin in cardiovascular disease, N/A is not applicable.

Article	Study Design	Population	Outcome Measures
Yen, K. et al. (2020) [40]	In vivo study	C. elegans, Mouse, Human	Circulating levels of humanin and their relation to diseases of aging and lifespan
Cai, H. et al. (2021) [72]	Review	N/A	Protective effect of humanin against oxidative stress
Conte, M. et al. (2019) [30]	In vivo study	Human	Aging; longevity. plasma levels of different mitokines
Gong, Z. et al. (2022) [49]	Review	Mouse, Porcine	Protective effect of humanin in myocardial ischemia-reperfusion.
Muzumdar, R.H. et al. (2010) [67]	In vivo study	Mouse	Intracardiac administration of a single dose of HNG at the time of ischemia or reperfusion reduces infarction size and improves cardiac function. Humanin attenuated protein levels of Bax in the heart following MI.
Thummasorn, S. et al. (2016) [68]	In vivo study	Mouse	HNG treatment reduced cardiac infarct size, improved the function of the left ventricle, and decreased cardiac arrhythmias during MI-R. HNG treatment improved cardiac mitochondrial function and decreased the mitochondrial ROS level in cardiac cells
Sharp, T.E., III et al. (2020) [71]	In vivo study	Porcine	A single dose of HNG, administered at the time of reperfusion, diminishes cardiac infarction size and inhibits cardiomyocyte apoptosis