Table 3.

Role of Humanin in inflammation, N/A is not applicable.

Article	Study Design	Population	Outcome Measures
Esterhuizen, K. et al. (2017) [80]	In vitro study	N/A	Role of HN against oxidative stress, apoptosis, and inflammatory response
Bachar, A.R. et al. (2010) [82]	In vitro study	N/A	HN attenuates inflammation and macrophage infiltration, reduces in vitro production of IL-6, IL-1β, and TNF-α
Nashine, S. et al. (2022) [94]	In vivo study	AMD patients AMD RPE transmitochondrial cybrid cells	Treatment with HNG can reduce plasma levels of inflammation-associated marker protein. In AMD RPE cybrid cells, treatment with HNG reduced CD62E/E-Selectin, CD62P/P-Selectin, ICAM-1, TNF-α, MIP-1α, IFN–γ, IL-1β, IL-13. and IL-17A
Conte, M. et al. (2021) [89]	In vivo study	Patients with T2D and AD	Plasma levels of fibroblast growth factor 21 (FGF21), growth differentiation factor 15 (GDF15), humanin, and mitochondrial stress-related mitokines
Conte, M. et al. (2019) [30]	In vivo study	Human	Aging; longevity; plasma levels of different mitokines
Merry, T.L. et al. (2020) [95]	In vivo study	Human	Plasma humanin levels in long-lived subjects