Table 5.

Role of Humanin in autophagy, N/A is not applicable.

Article	Study Design	Population	Outcome Measures
Miller, B. et al. (2022) [98]	Review	N/A	Aging; mitochondrial copy number; relative ratio of mtDNA to nuclear DNA, and autophagy
Li, P. et al. (2021) [107]	N/A	N/A	Autophagy in skeletal muscle
Sreekumar, P.G. et al. (2016) [114]	In vitro study	hRPE cells	Expression of humanin and its effect on oxidative stress-induced cell death; mitochondrial bioenergetics, and senescence.
Gong, Z. et al. (2018) [115]	In vitro study	N/A	Chaperone-mediated autophagy
Kim, S.J. et al. (2022) [116]	In vivo and in vitro study	HEK293 cells; Mouse; C. elegans; Human	Role of humanin in the activation and regulation of autophagy
Kim, S.J. et al. (2018) [124]	In vitro study	Primary senescent human fibroblasts	Number of mitochondria; levels of mitochondrial respiration; mtDNA methylation, and mitochondria-encoded peptides