Figure 2.

Cardiac-specific overexpression of PINK1 alleviated myocardial hypertrophy and fibrosis induced by transverse aortic constriction (TAC). Cardiac hypertrophy reflected by (A) HE staining in global and (B) protein expression of ANP and β-MHC (n = 3), and (C) WGA staining (n = 6). Collagen quantification was measured on Masson staining (D), Sirius Red staining (E) in detail (n = 6), and (F) protein (n = 3) expression of collagen 1 and TGF-β1; statistical analyses (A–F) were performed by one-way ANOVAs followed by Bonferroni test post-hoc tests. *: p < 0.05, **: p < 0.01, ***: p < 0.001. Data are presented as the mean ± SD.