Table 1.
The application of Sr compound with hydroxyapatite scaffolds.
| Year | Team | Materials | Results |
|---|---|---|---|
| 2018 | Luo et al. [54] | Sr-substituted HA scaffold | Increased adhesion, proliferation, and ALP activity of MC3T3-E1 |
| 2018 | Ge et al. [62] | Sr-composited HA porous poly scaffold | Increased adhesion, proliferation, and ALP activity of MC3T3-E1 |
| 2019 | Oryan et al. [55] | Incorporation of Sr and bioglass into G/nHAp scaffold | Increased expression of OPN, OCN, and angiogenic markers of BMSCs |
| 2020 | Geng et al. [56] | Nano-needle Sr-substituted apatite coating | Increased adhesion, spreading, proliferation, and osteogenic differentiation of BMSCs, inhibited differentiation of osteoclasts |
| 2020 | Chang et al. [57] | Sr-substituted calcium sulfate hemihydrate/HA scaffold | Increased proliferation, migration, mineralized nodule area, and differentiation into osteoblast-like cells of BMSCs |
| 2020 | Zhao et al. [59] | Sr-substituted HA scaffold | Increased expression of the osteogenic marker in BMSCs |
| 2021 | Ramadas et al. [58] | Sr-substituted HA scaffold | Increased proliferation of MG-63 |
| 2022 | Zhong et al. [60] | Zn/Sr dual ion-collagen co-assembly HA | Increased osteogenic differentiation of BMSCs |
| 2022 | Jiang et al. [61] | Bioactivity of HA doped with different levels of Sr ceramics | Increased the proliferation, ALP activity, and gene expression of osteogenic and angiogenic factors in BMSCs |
ALP: alkaline phosphatase, BMSCs: bone marrow mesenchymal stem cells, G/nHAp: gelatin/nano-hydroxyapatite, HA: hydroxyapatite, OPN: osteopontin, OCN: osteocalcin.