Table 2.

The application of Sr compound with bioactive glass.

Year	Team	Materials	Results
2017	Fernandes et al. [79]	Mg and Sr-substituted BGs	Increased osteogenic differentiation and expression of ALP, OPN, and OCN in BMSCs
2018	Naruphontjirakul et al. [69]	Sr-containing BG nanoparticles	Increased ALP activity and expression of OCN in MC3T3-E1
2018	Fiorilli et al. [72]	Sr-BGs	Increased osteogenic differentiation of SAOS-2
2018	Midha et al. [78]	Sr-BGs	Increased osteogenic differentiation of BMSCs
2019	Autefage et al. [75]	PSrBG	Increased proliferation of BMSCs and MC3T3-E1
2019	Shaltooki et al. [76]	BGs composed of PCL and different levels of Sr	Increased osteogenic activity of MG-63
2020	Huang et al. [49]	Sr-substituted BGs	Inhibited RANKL-mediated osteoclastogenesis
2021	Baheiraei et al. [70]	Gel-BG/Sr scaffolds	Increased bone formation
2021	Fiorilli et al. [73]	Sr-containing esoporous BGs	Inhibited osteoclast differentiation and function
2022	Wu et al. [74]	Sr-BG	Increased osteogenesis and angiogenesis of BMSCs

ALP: alkaline phosphatase, BMSCs: bone marrow mesenchymal stem cells, BGs: bioactive glasses, Gel-BG: gelatin-bioactive glasses, OPN: osteopontin, OCN: osteocalcin, PCL: polycaprolactone, PSrBG: porous, Sr-releasing and bioactive glass-based scaffold, RANKL: receptor activator of nuclear factor-κB ligand.