Table 3.

The application of Sr compound with calcium phosphates ceramics and bone cements.

Year	Team	Materials	Results
2018	Reitmaier et al. [92]	Sr(II)-doted CPC scaffolds	Increased bone formation
2019	Li et al. [91]	Sr-hardystonite-gahnite bioactive ceramic scaffold	Induced substantial bone formation and defect bridging
2020	Chen et al. [86]	Sr-substituted biphasic calcium phosphate microspheres	Increased proliferation and osteogenic inductivity of BMSCs
2020	Zeng et al. [87]	Sr-substituted calcium phosphate silicate bioactive ceramic	Increased proliferation and ALP activity of BMSCs, inhibited osteoclast differentiation
2020	Tohidnezhad et al. [88]	Sr-composited β-tricalcium phosphate scaffold	Increased bone fracture gap bridging
2020	Tao et al. [89]	Aspirin-modified Sr-composited β-tricalcium phosphate	Increased osteogenic viability of MC3T3-E1
2020	Wu et al. [31]	Sr-reinforced calcium phosphate hybrid cement	Increased ALP activity and osteogenic gene expression of BMSCs, and promoted bone regeneration
2021	Liu et al. [90]	Sr-substituted calcium silicate ceramics	Increased angiogenesis of BMSCs and accelerated bone regeneration

ALP: alkaline phosphatase, BMSCs: bone marrow mesenchymal stem cells, CPC: calcium phosphate cements.