Table 4.
The application of Sr compound with natural polymers.
| Year | Team | Materials | Results |
|---|---|---|---|
| 2018 | Cheng et al. [39] | SrCl-coated surface porous CPB scaffold containing PCL | Increased osteogenic differentiation of BMSCs |
| 2019 | Ye et al. [96] | Sr-composited calcium phosphate/polycaprolactone/chitosan nanohybrid films | Increased adhesion, proliferation, and vascular differentiation of BMSCs |
| 2020 | Luo et al. [99] | Sr-calcium sulfate hemihydrate scaffold containing ginsenoside Rg1-encapsulated gelatin microspheres | Increased osteogenic differentiation and ALP activity of MC3T3-E1 |
| 2021 | Ma et al. [97] | Sr Laminarin polysaccharide | Increased expression of OCN in MC3T3-E1 |
| 2021 | Wu et al. [98] | Biodegradable silk protein-gelatin scaffolds doped with SrP and ginsenoside Rg1 | Increased osteogenic differentiation of BMSCs |
| 2021 | Xu et al. [100] | Metformin hydrochloride encapsulated Sralginate hydrogel | Increased chondrocyte repair, inhibited expression of senescence apoptosis, oxidative, and inflammatory genes |
| 2021 | Xu et al. [101] | Chitosan-Sr sulfate chondroitin scaffold | Increased BMP-2 expression of MC3T3-E1 |
| 2022 | Hassani et al. [102] | Alginate-nano-hydroxyapatite-collagen microspheres mixed with Ca2+, Ba2+, and Sr2+ | Increased the viability and osteogenic capacity of osteoblasts |
ALP: alkaline phosphatase, BMSCs: bone marrow mesenchymal stem cells, BMP-2: bone morphogenetic protein-2, CPB: calcined porcine bone, OCN: osteocalcin, PCL: polycaprolactone.