Table 6.
The application of Sr compound with metal-based materials.
| Year | Team | Materials | Results |
|---|---|---|---|
| 2017 | Mi et al. [109] | Sr-loaded Ti dioxide nanotube | Inhibited osteoclast differentiation |
| 2018 | Choi et al. [111] | Sandblasted/acid-etched titanium implants with Sr-containing nanostructures | Increased osteogenic differentiation of BMSCs and expression of osteogenic genes in osteoblasts |
| 2019 | Zhou et al. [114] | Sr-composited titanium dioxide coating | Increased proliferation and osteogenic differentiation of BMSCs |
| 2019 | Li et al. [115] | Dual delivery system coated on Ti surface | Manipulated macrophage polarization to activate pre-osteoblast differentiation |
| 2019 | Lin et al. [117] | Sr-incorporated titanium implant | Increased effect of early bone healing |
| 2020 | Ding et al. [112] | Protein supramolecular nanomembranes doped with Sr on Ti base | Increased early adhesion, proliferation, osteogenic differentiation, and expression of osteogenic genes in BMSCs |
| 2020 | Jia et al. [118] | Zn-Sr alloy | Increased cytocompatibility and osteogenesis of MC3T3-E1 |
| 2020 | Zhang et al. [119] | Mg-Sr alloy | Increased proliferation, mineralization, and ALP activity of BMSCs |
| 2021 | Xu et al. [113] | Sr-Ti implants | Increased OPG expression and lowered inflammatory factors expression |
| 2022 | Su et al. [110] | Sr calcium phosphate coating on Ti6Al4V scaffolds | Increased adhesion, spreading, and osteogenesis of BMSCs |
| 2022 | Li et al. [116] | Sr-doped titanium dioxide mesoporous nanospheres | Increased the formation of new bone tissue |
ALP: alkaline phosphatase, BMSCs: bone marrow mesenchymal stem cells, OPG: osteoprotegerin, Ti: titanium.