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. 2023 Apr 11;10(4):464. doi: 10.3390/bioengineering10040464

Figure 2.

Figure 2

Macroscopic changes upon PDT treatment. (A) Examples of blood vessel fragmentation within (upper panel, compare zoom-ins before and after PDT) and surrounding (lower panel, indicated by white arrows) the tumor. Twenty-four hours after PDT, tumors presented as either hemorrhagic (upper panel) or ischemic (lower panel). (B) For a subgroup of tumors, PPIX fluorescence intensity was measured before (pre-PDT) and 1 h after PDT (post-PDT). The fold change (FC) in mean grey value of tumor against the background is depicted. Statistical analysis: paired Student’s t-test. M4M51 = Ewing sarcoma; MFS-SN1 = myxofibrosarcoma.