Table 2.
Matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases identified in patients with hypertrophic cardiomyopathy.
| Subgroup | MMP | Nomenclature | Mass (kDa) | Substrate | References |
|---|---|---|---|---|---|
| Interstitial collagenase | MMP-1 | Fibroblast collagenase | 52 | Collagens I, II, III, VI, VIII and X, gelatin, aggrecan, MMP-2, MMP-9 | [11,12,15,19,21] |
| MMP-8 | Neutrophil collagenase or Collagenase 2 | 75 | Collagens I, II, III, V, VII, VIII and X, gelatin, aggrecan | [10] | |
| MMP-13 | Collagenase 3 | 54 | Collagens I, II, III and IV, gelatin, aggrecan | [10] | |
| Gelatinases | MMP-2 | Gelatinase A | 72 | Gelatin, collagen types I, IV, V, VII, X, XI and XIV, elastin, fibronectin, aggrecan | [10,11,13,15,16,17,18,19,20,21,23,24,25] |
| MMP-9 | Gelatinase B | 92 | Gelatin, collagen types IV, V, VII, and X, elastin | [10,11,13,15,17,18,19,20,21,22,23,25] | |
| Stromelysins | MMP-3 | Stromelysin 1 | 57 | Collagens III, IV, IX and X, gelatin, aggrecan, MMP-1, MMP-7, MMP-8, MMP-9 and MMP-13, laminin, fibronectin, non-helical collagen | [13,19,21] |
| Glycoproteins | TIMP-1 | - | 28 | all MMPs except MMP-14 | [10,11,12,13,15,16,17,18,19,20,21,23,25] |
| TIMP-2 | - | 21 | all MMPs | [13,19,20] | |
| TIMP-3 | - | 24 | all MMPs | [19] | |
| TIMP-4 | - | 23 | all MMPs | [14,19] |
Abbreviations: MMP, matrix metalloproteinases; TIMP, tissue inhibitor of matrix metalloproteinase.