Experimental procedure in each fatigued person with MS undergoing Faremus treatment. Left from top: Individual brain MRI-based personalized electrode shaping [ES (A)] performed once before tDCS sessions. In blocks 1 and 2 (equal, but the 5 −day stimulation is either real or sham based on random assignment), after the data collection (pre-Faremus), the electrode positioning [EP, (B)] is executed before each 15 min stimulation [tDCS, (C)] of each of the 5 days of treatment. On the day of the last tDCS, we performed the data collection (post-Faremus). Right: Data collection (pre − and post −Faremus) includes the fatigue level assessment (modified fatigue impact scale, mFIS) and the collection of left/right opponens pollicis (OP) motor-evoked potential (MEP) by TMS, used for corticospinal tract excitability and inter-side homology assessment.