Table 2.

Hazard ratios for breast cancer death after local recurrence, all patients.

Variable	Univariate HR (95% CI) P	Multivariate HR (95% CI) P
Age at diagnosis (years)
<40	1	1
40–49	0.40 (0.16–1.04) 0.06	0.47 (0.18–1.23) 0.12
50–59	0.55 (0.21–1.44) 0.22	0.48 (0.18–1.30) 0.15
60+	0.35 (0.13–0.93) 0.03	0.23 (0.08–0.66) 0.006
Tumour size
0–2 cm	1	1
2–5 cm	2.53 (1.18–4.64) 0.02	1.79 (0.84–3.82) 0.13
Grade
1	1
2	2.42 (0.87–7.86) 0.09
3	3.05 (1.00–9.27) 0.05	Not used
ER status
Negative	1	1
Positive	0.59 (0.31–1.12) 0.10	0.81 (0.37–1.79) 0.61
PR status
Negative	1	1
Positive	0.33 (0.17–0.64) 0.001	0.34 (0.16–0.73) 0.006
LVI
No	1	1
Yes	1.86 (0.92–3.79) 0.08	Not used
Oophorectomy
No	1
Yes	0.47 (0.11–1.94) 0.29	Not used
HER2 status
Negative	1
Positive	1.19 (0.40–3.53) 0.75	Not used
Radiation at diagnosis
No	1	1
Yes	1.70 (0.84–3.44) 0.14	1.86 (0.80–4.35) 0.15
Tamoxifen
No	1	1
Yes	1.43 (0.74–2.74) 0.29	1.06 (0.52–2.19) 0.87
Time diagnosis to local recurrence
0–1.99 years	1	1
2 and +	0.46 (0.22–0.94) 0.04	0.38 (0.17–0.85) 0.02