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Histological patterns of the idelalisib-induced colitis in the study patients. (A,B) Mild crypt distortion without any other anomaly (case 1). (C,D) Acute inflammatory changes, crypt abscess, IBD/ulcerative colitis-like (cases 3 and 5). (E,F) Withering crypt, fibrosis of the lamina propria, chronic ischemic-like lesion (case 4). (G,H) Apoptotic predominant aspect, GVH-like (cases 2 and 6). (A,E) ×25; (C,G) ×100; (B,F) ×200; (D,H) ×400.
