Table 1.

Expression and clinical significance of OTUD5 in various cancers.

Target Substrate	Tumor Type	Result of Deubiquitination	Affected Pathway or Event	Effect	References
βTrCP1	Colon cancer Breast cancer	Stable protein	mTOR pathway	Enhanced cancer cell proliferation	[10]
RNF186	Bladder cancer	Stable protein	mTOR pathway	Enhanced cancer cell progression	[11]
YAP	Triple-negative breast cancer	Stable protein	Hippo pathway	Enhanced cancer cell metastasis	[12]
TRIM25	Hepatocellular carcinoma and non-small cell lung cancer	Decreased transcriptional activity	-	Reduced tumor growth	[7]
P53/PDCD5	Non-small cell lung cancer	Stable protein	Apoptosis	Reduced cancer cell proliferation and metastasis	[8]
PTEN	Non-small cell lung cancer	Stable protein	Akt signaling	Inhibited proliferation, invasion and migration	[9]
Akt	Cervical cancer	Stable protein	Akt signaling	Sensitive to radiotherapy	[73]