Table 4.

Performance of 26 Biomarkers for Discerning Between the Actionable and Non-actionable Cohorts. Individual biomarker performances were compared between actionable and non-actionable nodules via the Mann–Whitney U Test.

Protein Name	Uniprot ID	Non-Actionable Median (Range), ng/mL	Actionable Median (Range), ng/mL	p-Value
MID1IP1	Q9NPA3	71.25 (17.85–388.06)	142.49 (0.14–397.30)	4.30 × 10−29
PNMA1	Q8ND90	15.59 (0.19–94.31)	30.99 (0.25–93.93)	1.05 × 10−20
PGAM1	P18669	5.25 (0.11–30.96)	9.74 (0.02–31.27)	4.86 × 10−15
HNRNPD	Q14103-1	13.23 (0.19–85.85)	23.71 (0.09–90.12)	7.83 × 10−14
MED21	Q13503	45.12 (1.59–229.99)	65.03 (0.1–231.13)	1.60 × 10−9
IMPDH2	P12268	316.41 (30.23–1685.81)	481.49 (8.89–1686.36)	1.83 × 10−7
SGPL1	O95470	7866.32 (6.02–77,865.4)	14,005.25 (0.15–78,349.22)	3.65 × 10−7
ZNF696	Q9H7X3	112.12 (4.38–404.82)	87.71 (21.5–393.02)	2.18 × 10−6
GPBP1	Q86WP2	42.09 (0.18–275.87)	65.18 (0.05–278.53)	2.39 × 10−5
Annexin 2	P07355	17.27 (0.01–228.71)	26.81 (0.28–245.76)	4.15 × 10−5
NAT9	Q9BTE0	1155.48 (45.72–4082.57)	1551.26 (7.44–4304.02)	8.67 × 10−5
TP53	P04637	43.78 (0.75–234.93)	59.04 (0–236.63)	0.0003
Annexin 1	P04083	0.96 (0.01–8.44)	1.34 (0–8.51)	0.014
NIP30	Q9GZU8	4.91 (0.03–29.18)	5.96 (0.01–29.71)	0.014
TAF10	Q12962	164.68 (5.48–584.71)	147.65 (26.31–567.49)	0.023
RAB27A	P51159	0.54 (0.01–2.70)	0.67 (0.01–2.73)	0.027
KEAP1	Q14145	6.12 (0.06–29.3)	8.24 (0.01–30.98)	0.041
Ubiquillin 1	Q9UMX0	4.73 (0.2–42.17)	484.48 (9.02–5403.48)	0.077
HSP70	P0DMV9	0.7 (0–2.73)	0.8 (0.09–2.74)	0.163
MYBPH	Q13203	436.92 (3.36–1721.33)	385.88 (0.66–1760.32)	0.211
NAP1L5	Q96NT1	587.41 (2.02–2535.53)	632.27 (0.51–2399.45)	0.234
IKZF5	Q9H5V7	46.96 (0.06–331.96)	49.68 (0.07–338.83)	0.258
Ubiquillin2	Q9UHD9	99.87 (2.39–499.05)	84.37 (0.65–506.10)	0.454
Dr1	Q01658	18.05 (0.01–97.89)	20.58 (0.02–94.76)	0.507
DCD	P81605	2022.34 (71.6–6775.07)	2120.54 (345.25–6768.67)	0.539
CFAP36	Q96G28	27.08 (0.04–109.11)	27.74 (0.03–112.46)	0.631