. 2023 Apr 9;12(8):1118. doi: 10.3390/cells12081118

Table 1.

Comparison of the role of adipocytokines in different cancers. Adipocytokines in the pathomechanism of individual cancers manifest elevated or reduced concentrations with respect to reference values. The table considers this criterion, graphically assigning an arrow symbol: ↑—indicates elevated concentrations of adipocytokines, ↓—indicates decreased concentrations of adipocytokines, and the symbol ↑↓ indicates that both elevated and decreased concentrations of adipocytokines are involved in the mechanism of cancer pathogenesis.


Leptin	increase in tumor mass, facilitated metastatic ability, effect the process of angiogenesis, prevention of apoptosis of tumor cells [101,107,108,109,110]	stimulation of cancer cell proliferation, inhibition of apoptosis, promotion of malignant cancer phenotypes, reduced survival rate [106,111,112]	metastatic capacity, proliferation of cancer cells, induction of chemoresistance [30,41,105]
Adiponectin	inhibition of cell cycle, blocking angiogenesis, induction of apoptosis [118,119,130,131,295]	inhibition of angiogenesis, growth and proliferation, invasion, migration, formation of tumor metastases [62,108,114,127,133,134]	increase in cancer risk and stage [114,131,137]
Visfatin	increase in risk of cancer development, shortened survival time, proliferation of cancer cells, metastasis formation [151,152,296]	promotion of process of carcinogenesis, stimulation of process of angiogenesis, promotion of metastases formation [155,156,157,161,162]	proliferative, proangiogenic effects, facilitated ability to form metastases [41,169,171]
Resistin	facilitation of cancer growth and development, increase in cancer stage, metastatic ability, increase in aggressiveness [53,54,94,162]	ability to promote and progress cancer, metastatic formation, angiogenesis promotion, induction of chemoresistance [53,178,184,185]	facilitation of growth and development of cancer, ability to metastasize, increase in stage of progression, decrease in survival rate [41,173,178,187,188]
Apelin	advanced stage of cancer, presence of metastases, induction of angiogenesis, poor prognosis [200,204,205,206]	survivability, proliferation of cancer cells, metastasis formation, shortened survival time [203,208,211]	increase in cancer risk in women with obesity [205,212,213]
Chemerin	migration of immune system cells toward the tumor, intracellular signaling, facilitated angiogenesis [215,218,229,245,246,247,248,297]	effect on cancer cell adhesion, metastatic capacity [229,249,250]	no data available
Omentin	stimulation of cancer growth and development, metastasis formation, inhibition of proliferation, induction of apoptosis [268,269,270]	proliferation of tumor cells, metastasis formation [268,271,272]	increase in stage of cancer [273,274,275]
Vaspin	increase in degree of malignancy of cancer, decrease in survival time, formation of metastasis [44,287]	stimulation of process of angiogenesis, limiting the process of apoptosis [203,278,280]	increase in risk of developing cancer, increase in stage of cancer [171,174,293,294]