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A scheme of CRISPR-Cas9 engineering in autologous CAR-T therapy. T cells are extracted from cancer patients and engineered with CRISPR-Cas9 to edit select genes. Later, chimeric antigen receptor (CAR) is randomly inserted into the genome via lentivirus or precisely engineered into a target locus via the CRISPR-Cas9 system to create an engineered autologous CAR-T cell. Engineered CAR-T cells are later given back to the cancer patients.
