Table 4.
List of CRISPR-Cas-based gene editing therapies for infectious diseases.
| Condition Targeted | Gene Target | Edit Type | Therapeutic | Sponsor | Clinical Trial ID |
|---|---|---|---|---|---|
| HIV-1 | HIV proviral DNA | Viral genome split (NHEJ) | EBT-101 | Excision Biotherapeutics | NCT05144386 [125] |
| NCT05143307 [126] | |||||
| HPV | E6/E7 genes of HPV16/18 | Viral genome split (NHEJ) | Talen: TALEN-HPV16 E6/E7 or TALEN-HPV18 E6/E7; CRISPR-Cas9: CRISPR/Cas9-HPV16 E6/E7T1 or CRISPR/Cas9-HPV18 E6/E7T2 | First Affiliated Hospital, Sun Yat-sen University | NCT03057912 [132] |
| Viral keratitis | HSV-1 genome | Viral genome split (NHEJ) | CRISPR/Cas9 mRNA | Shanghai BDgene Co., Ltd. | NCT04560790 [135] |