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. 2023 Apr 18;12(8):1179. doi: 10.3390/cells12081179

Table 1.

Summary of NuRD and CHD genes associated with neurodevelopmental disorders.

Gene Neurodevelopmental Disorders
NuRD Subunits
CHD3 Craniofacial defects, developmental delay, language deficits
(Snijders Blok–Campeau syndrome) [50]
CHD4 Developmental delay, speech and motor delay, cognitive impairment
(Sifrim–Hitz–Weiss syndrome) [51,52]
CHD5 Language deficits, intellectual disability, epilepsy, behavioural disorder
(Parenti–Mignot neurodevelopmental syndrome) [53]
GATAD2B Motor disability, intellectual disability, language deficits, developmental delay, craniofacial abnormalities
(GATAD2B-associated neurodevelopmental disorder) [54]
MBD3 Non-verbal ASD [55,56]
Other CHDs
CHD2 Epilepsy, neurobehavioural disorders, intellectual disability [57,58]
CHD7 Intellectual disability, hearing and visual impairments, developmental delay, self-injurious behaviour, sleep problems
(CHARGE syndrome) [59,60,61]
CHD8 Developmental delay, ASD, behavioural disorder, musculoskeletal defects
(Intellectual developmental disorder with autism and macrocephaly, IDDAM) [62,63,64]