Figure 7.

NK cell-based immunotherapy for metastasis therapy. NK cells are known for killing tumor cells without prior stimulation, thus participating in the first line of defense against malignant transformation and metastasis. Multiple strategies aimed at activating NK cell immunosurveillance have demonstrated substantial therapeutic effects in preclinical models of metastatic dissemination. Most therapeutic strategies currently employed in the clinic stem from restoring NK cell activation-dependent immune responses against metastatic cancers.