Table 2.
Current clinical trials for the prevention and treatment of chemotherapy-induced alopecia (clinicaltrials.gov).
| Category | NCT Number |
Interventions | Completed | Recruiting | Not Yet Recruiting | Device | RCT, Parallel Assignment |
Single Group Assignment |
Open Label | Gender | Target Sample Size/Enrollment | Prevention | Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Scalp cooling | NCT01831024 | Dignicap System | * | X | Non-R CT | X | Female | 110 | X | ||||
| NCT03712696 | Device: DIGNICAP™ | X | X | X | X | Female | 139 | X | |||||
| NCT04630080 | Scalp cooling | X | X | X | X | Female | 100 | X | |||||
| NCT05213936 | Scalp cooling with hairstyle using conditioner and water emulsion | X | X | Non-R CT | Single blind (Investigator) | All | 30 | X | |||||
| NCT03248193 | Concomitant limb cryocompression and scalp cooling |
* | X | Non-R CT | X | All | 50 | X | |||||
| NCT04986579 | Paxman Scalp Cooling System | X | X | Non-R CT | X | All | 120 | X | |||||
| NCT01008774 | Paxman Cooling Machine; Cold Caps |
X | X | Non-R CT | X | All | 239 | X | |||||
| NCT04180579 | PAXMAN Scalp Cooler | ** | X | X | X | Female | 34 | X | |||||
| NCT04764357 | Paxman Scalp Cooling System | X | X | X | X | All | 40 | X | |||||
| NCT04117815 | Paxman Scalp Cooling System | X | X | *** | Female | 128 | X | ||||||
| NCT04626895 | Paxman Scalp Cooling Device | X | X | X | X | Female | 15 | X | |||||
| NCT05533320 | Paxman Scalp Cooling System | X | X | X | X | Female | 30 | X | |||||
| NCT04678544 | Paxman Scalp Cooling System 2 | X | X | X | Single blind (Outcomes Assessor) | Female | 170 | X | |||||
| NCT04168242 | Scalp cooling Paxman Orbis II system |
** | X | X | X | Female | 80 | X | |||||
| NCT01986140 | PAXMAN Orbis Scalp Cooler Treatment with Orbis scalp cooling cap | ** | X | X | Single blind (Care Provider) | Female | 236 | X | |||||
| NCT03289364 | Penguin Cold Caps | * | X | X | X | All | 9 | ||||||
| NCT05484973 | AMMA Portable Scalp Cooling System | X | X | X | X | Female | 125 | X | |||||
| NCT05365243 | AMMA Portable Scalp Cooling System | X | X | X | X | Female | 12 | X | |||||
| NCT03711877 | Scalp cooling system; chemical cold cap | X | X | X | X | Female | 256 | X | |||||
| PBMT | NCT05177289 | Theradome® LH80 pro combined with scalp cooling | X | X | X | Single blind (Outcomes Assessor) | Female | 72 | X | X | |||
| NCT04036994 | Photobiomodulation therapy | X | X | X | Single blind (Participant) | Female | 30 | X | |||||
| NCT05397457 | Low-level light therapy | X | X | X | X | Female | 88 | X | |||||
| Topical | NCT02919735 | Topical CG 428 herbal medicinal solution | X | X | Double blind (Participant, Investigator) | Female | 40 | X | X | ||||
| NCT02986412 | Topical CG 428 herbal lotion |
X | X | X | Female | 19 | X | ||||||
| NCT02605629 | Topical CG 428 herbal lotion |
X | X | Double blind (Participant, Investigator) | Female | 32 | X | ||||||
| NCT04554732 | Topical Keratinocyte growth factor | X | X | X | Female | 28 | X | ||||||
| NCT01588522 | Topical compound 31, 543 Calcitriol | X | X | X | All | 30 | X | ||||||
| Oral | NCT03831334 | Drug: oral minoxidil | X | X | X | All | 25 | X | |||||
| Injection | NCT04459650 | Platelet Rich Plasma | ** | X | X | All | 30 | X | |||||
| - | NCT02530177 | Clinical Assessment of alopecia and pCIA, skin aging and nail changes: Observational |
** | **** | Female | 546 | - | - |
*: Unknown status; **: Active, not recruiting; ***: Observational Model: Cohort; ****: Observational Model: Case-Control. RCT: Randomized controlled trial; Non-R CT: Non-randomized controlled trial. Note: NCT00999557 to evaluate the efficacy of topical Bimatoprost in promoting eyebrow and eyelashes has been withdrawn. NCT02797223, an interview-based quality of life study supposed to be completed by December 2016, was excluded.