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. 2023 Apr 18;15(8):2363. doi: 10.3390/cancers15082363

Figure 1.

Figure 1

SLC7A11/xCT is overexpressed in human colorectal cancer. (A) SLC7A11 mRNA expression level in microsatellite instable (MSI) CRC patients vs. microsatellite stable (MSS) CRC patients. Correlation of SLC7A11 expression with the (B) Buffa hypoxia score, (C) Winter hypoxia score, and (D) the Ragnum hypoxia score. (E) Representative blot showing the expression levels of xCT in DLD-1 and HCT116 cell lines under normoxic (21%) and hypoxic (1%) conditions, using alpha-tubulin as the reference gene. (F) Summarizing graph showing the quantitative values of the western blot. Data are shown as mean ± SEM, n > 3. An unpaired t-test was used in the case of a normal distribution (panel (A)), while a Mann Whitney test was used if normality was not present (panels (B–D)), or a two-way ANOVA followed by Bonferroni’s test (panel (F)) was used for statistical analyses. ** p < 0.01, *** p < 0.001, **** p < 0.0001. The uncropped blots are shown in Figure S3.