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. 2023 Apr 18;15(8):2363. doi: 10.3390/cancers15082363

Figure 2.

Figure 2

Inhibition of xCT radiosensitizes human hypoxic colorectal cancer cells. DLD-1 and HCT116 were treated with different concentrations of SSZ (16 h) and irradiated with the indicated doses. The radiosensitizing effect was evaluated by colony formation assays. (A,B) Dose-response curve of the DLD-1 cell line under normoxic conditions (21% O2) (A) or hypoxic conditions (0.1% O2) (B). (C,D) Dose-response curve of the HCT116 cell line under normoxic conditions (21% O2) (C) or hypoxic conditions (0.1% O2) (D). Data are shown as mean ± SEM, n ≥ 3. A two-way ANOVA followed by Dunnett’s multiple comparison test was used to calculate statistics. * p < 0.05, *** p < 0.001, **** p < 0.0001.