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. 2023 Mar 31;13(4):595. doi: 10.3390/brainsci13040595

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The flowchart of imaging processing. The image processing pipelines are mainly divided into three steps: preprocessing step (this mainly includes visual image quality checking using the software RadiAnt DICOM Viewer (https://www.radiantviewer.com/, accessed on 20 April 2022), converting the image format from DICOM into NIFIT using MRIcroGL; obtaining measurement maps using FSL and DKE together); and two-way registration (MD and MK maps were normalized into standard space using FSL based on Linux system. Firstly, the b0 image was registered into native T1 space using “flirt”; secondly, native T1 was normalized into MNI T1 space using “fnirt”; thirdly, the transformations from the last two steps were applied to native MD/MK and aligned into standard space and extraction of values using “fslmeants”.