Figure 2.

Pre- and postnatal imaging findings of a patient with holoprosencephaly: (a–c) Prenatal MRI of a patient with semilobar holoprosencephaly. (a) Sagittal T2-weighted image shows a mass of parenchymal mantle anteriorly, and partial development of occipital lobes. (b) Coronal T2-weighted image shows a large monoventricle and thalami lying very close to one another. (c) Axial T2-weighted image shows a supratentorial monoventricle but with two distinct occipital horns. (d–f) Postnatal MRI of the same patient, 3 days old. (d) Sagittal T1-weighted image shows hypoplastic occipital lobes, partially absent anterior corpus callosum. (e) Coronal T2-weighted image shows bilateral fusion of the bilateral thalami (white asterisk) with severe hypodevelopment of the basal ganglia. (f) Axial T2-weighted image shows fusion of the frontal lobes (white arrows) and abnormal orientation of the rudimentary sylvian fissures with diffused decreased degree of sulcation.