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. 2023 Apr 7;13(4):632. doi: 10.3390/brainsci13040632

Figure 6.

Figure 6

EGCG downregulates MIF, CCL2, and TNFS10. PCR array evaluation of BV-2 cells demonstrated that EGCG 150 µM + LPS reduces the mRNA expression of proinflammatory mediators: MIF (A), CCL2 (B), and TNFS10 (C). LPS 1 µg/mL considerably elevated mRNA expression of MIF, CCL2, and TNFS10 when contrasted to 150 µM and 1 µg/mL LPS. The controls (untreated cells and EGCG 150 µM alone) varied in expression due to the effects of EGCG on these specific genes. Values represent the mean ± SD, *** p ≤ 0.001, and **** p ≤ 0.0001 vs. LPS.