Table 6.
Multivariable Cox-Proportional Hazards Modelling of overall survival (OS) for EGFR-altered NSCLC patients with brain metastases in first-line EGFR-TKI.
| Variable | Level | HR (95% CI) | p-Value |
|---|---|---|---|
| Karnofsky performance status | ≥70 | Reference | |
| <70 | 2.03 (0.57, 7.20) | 0.28 | |
| Extracranial metastases at diagnosis | Absent | Reference | |
| Present | 3.10 (1.42, 6.76) | 0.004 | |
| Whole-brain radiotherapy | No | Reference | |
| Yes | 1.58 (0.83, 3.01) | 0.17 | |
| Age | - | 1.01 (0.99, 1.03) | 0.46 |
| Leptomeningeal metastases | Absent | Reference | |
| Present | 0.71 (0.26, 1.92) | 0.50 | |
| Generation of EGFR TKI | 1st | Reference | |
| 3rd | 1.25 (0.63, 2.49) | 0.52 |