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. 2023 Apr 13;15(8):2268. doi: 10.3390/cancers15082268

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mannose and 5-FU combination treatments sensitize the human colorectal cancer cells relative to the 5-FU treatment. (A) HCT116 p53^−/−; (B) HCT116-5FUR cells. MTT results are expressed as a percentage of the control and represent the average of three independent experiments ± SEM. The asterisk represents the lowest concentration showing a significant decrease in cell viability in treated versus control cells. Significance from the control is indicated by * p < 0.05, ** p < 0.01, and *** p < 0.001.