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Mannose- and 5-FU-treated colorectal cancer cells induce DNA damage. (A) HCT116, (B) HCT116 p53−/− and (C) HCT116 5FU resistant (HCT116-5FUR) cells were treated with mannose (50 mM) and/or 5-FU (5 µM) for up to 72 h. Total SDS protein lysates were immunoblotted against PARP and γ H2AX antibodies. GAPDH was used as a loading control. This is a representative blot of three independent experiments.
