Figure 9.

Body weights and tumor volumes of NOD/SCID mice treated with mannose alone, 5-FU, or in combination. Here, 5 × 10⁶ HCT116 cells were injected subcutaneously into the flank of NOD/SCID mice. After tumor development, mice were divided into 4 groups: control, mannose, 5-FU, and mannose/5-FU. (A) Body weights were measured over time and represented among the four groups. Tumor volumes were measured over time and represented among the four groups, including (B) males and females, (C) males only, and (D) females only. * p < 0.05, ** p < 0.01, and *** p < 0.001 are considered statistically significant.