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. 2023 Apr 7;15(8):2198. doi: 10.3390/cancers15082198

Figure 2.

Figure 2

Effect of AR activation on cell proliferation: (A) Prolonged AR activation reduced androgen-responsive 84E7 cell growth in a concentration-dependent manner. (B) Parental androgen-unresponsive 8505C cells continued to proliferate at the same rate upon prolonged AR activation. (C) In the presence of both flutamide and DHT, 84E7 cells continued to proliferate and reach confluency. (D) AR activation reduced proliferation in lentivirus-induced androgen-responsive thyroid cancer cell line, 8505C-lentiAR. (E) AR activation reduced proliferation in lentivirus-induced androgen-responsive thyroid cancer cell line, K1-lentiAR. Data are expressed as raw numbers obtained from cell counts, and the asterisks denote statistically significant differences (* p-value < 0.05, ** p-value < 0.005, *** p-value < 0.0005).