Table 1.

Treatment protocols for various stages of HER2-positive breast cancer.

Breast Cancer Description	Treatment Protocol	Reference
Early-stage breast cancer (adjuvant/neoadjuvant)	Chemotherapy, Trastuzumab, Pertuzumab	[49]
Metastatic breast cancer
First-line therapy	Taxane, trastuzumab, pertuzumab	[50,51]
Second-line therapy	Trastuzumab emtansine	[52,53]
Third-line therapy	Capecitabine, lapatinib	[54]
	Aromatase inhibitor Trastuzumab/lapatinib	[55]
	Chemotherapy, trastuzumab	[56]
	Lapatinib, trastuzumab	[57]
	Vinorelbine, trastuzumab	[58,59]