Table 2.
MicroRNAs that mediate extravasation in breast cancer brain metastasis.
| MiR | Target | Mechanism | Regulation in Breast Cancer BM | Reference |
|---|---|---|---|---|
| MiR-1258 | HPSE | Increases HPSE expression and activity, mediating BM. | Downregulation | [52] |
| MiR-509 | TNF-α and RhoC-induced MMP9 | Induces BBB permeability and TEM. |
Downregulation | [84] |
| MiR-101-3p | COX2-MMP1 | Degrades BE protein junctions (VE-cadherin and claudin-5). | Downregulation | [85] |
| MiR-101-3p and miR-26-5b | COX2-MMP1 | Degrades BE protein junctions (claudin-5, VE-cadherin, ZO-1, and β-catenin). | Downregulation | [86] |
| MiR-202-3p | MMP1 | Degrades BE protein junction (ZO-1, claudin-5, and β-catenin). | Downregulation | [87] |
| MiR-623 | MMP1 | Degrades BE protein junction (VE-cadherin and claudin-5). | Downregulation | [88] |
| MiR-105 | ZO-1 | Disrupts BE. | Upregulation | [89] |
| MiR-181c | PDPK1 | Delocalizes actin fiber, inducing the destruction of BBB. | Upregulation | [90] |