Table 3.
Intravenous desensitization protocol of Case 3
| Solution type | Solution content | Concentration | ||||
|---|---|---|---|---|---|---|
| A | 10 mL solution B + 90 mL 0.9% NaCl | 0.002 mg/mL (1/1,000) | ||||
| B | 10 mL solution C + 90 mL 0.9% NaCl | 0.02 mg/mL (1/100) | ||||
| C | 10 mL solution D + 90 mL 0.9% NaCl | 0.2 mg/mL (1/10) | ||||
| D | 140 mL drug (700 mg) +210 mL 0.9% NaCl | 2 mg/mL (1/1) | ||||
| Step | Solution type | Rate, mL/h | Infusion duration, min | Volume infused per step, mL | Dose administered with this step, mg | Cumulative dose, mg |
| 1 | A | 2 | 15 | 0.5 | 0.001 | 0.001 |
| 2 | A | 4 | 15 | 1 | 0.002 | 0.003 |
| 3 | A | 8 | 15 | 2 | 0.004 | 0.007 |
| 4 | A | 16 | 15 | 4 | 0.008 | 0.015 |
| 5 | B | 4 | 15 | 1 | 0.02 | 0.035 |
| 6 | B | 8 | 15 | 2 | 0.04 | 0.075 |
| 7 | B | 16 | 15 | 4 | 0.08 | 0.155 |
| 8 | B | 32 | 15 | 8 | 0.16 | 0.315 |
| 9 | C | 8 | 15 | 2 | 0.4 | 0.715 |
| 10 | C | 16 | 15 | 4 | 0.8 | 1.515 |
| 11 | C | 32 | 15 | 8 | 1.6 | 3.115 |
| 12 | C | 64 | 15 | 16 | 3.2 | 6.315 |
| 13 | D | 16 | 15 | 4 | 4 | 14.31 |
| 14 | D | 32 | 15 | 8 | 16 | 30.31 |
| 15 | D | 52 | 15 | 13 | 26 | 56.31 |
| 16 | D | 52 | 341 | 296 | 592 | 648 |
Dose: 40 mg/kg/day; the patient's weight: 16.2 kg; total volume: 373.5 mL. NaCI, sodium chloride; alglucosidase alfa (Myozime®) = 50 mg = 10 mL.