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Exploration of the association of tumor metastasis with BNIP3. (A) Correlations between BNIP3 and osteosarcoma metastasis are displayed in box plots. ROC curve of diagnosis of osteosarcoma metastasis by BNIP3 in the training set (B) and in the entire cohort (C). (D) Relationship between the expression of BNIP3 and the expression of tumor metastasis-related genes MYC, NELL1, SAR1A, PLOD2, TNFAIP8L1, and TRIM22. (E,F) Expression of BNIP3 in different tumors. “*”represented “p < 0.05”.
